Casting Les Griffin
S08E11 Star Trek, le retour

Wil Wheaton
Wil Wheaton

Rob Lowe
Rob Lowe

Jonathan Frakes
Himself

Levar Burton
Himself

Seth Green
Chris Griffin

Mila Kunis
Meg Griffin

Alex Borstein
Lois Griffin

Brent Spiner
Himself

Max Burkholder
Calvin

Denise Crosby
Herself

Seth MacFarlane
Jack Daniels / Dr. Elmer Hartman / Tom Tucker / Glenn Quagmire / Stewie Griffin / Brian Griffin / Pe

Marina Sirtis
Herself

Patrick Stewart
Himself

Michael Dorn
Himself

Adam West
Himself / Mayor Adam West

Alexandra Breckenridge
Hot Date

Alec Sulkin
Trekkie #3 / Jesus Christ / Co-Pilot / Announcer #10

David A. Goodman
Trekkie #1

Lori Alan
Diane Simmons

Steve Callaghan
Employee

Mark Hentemann
Trekkie #2

Gates McFadden
Herself

Patrick Meighan
Jeremy Miller

John Viener
Pilot / Lead Singer / Jagermeister / TV Announcer

Mike Henry
TV Announcer / Cleveland Brown

Danny Smith
Gypsy / Guy with Mumps / Beer Can

Chris Cox
Kirk Cameron

John G. Brennan
Zima Bottle (voice) (as Johnny Brennan)